Daniel Chang, M.D.  Associate Sue and Bob McCollum Professor in Radiation Oncology

Research description: Dr. Chang specializes in radiation therapy of gastrointestinal cancers, and has a particular interest in stereotactic body radiotherapy (SBRT) and biomarkers for treatment response.  The role of SBRT for GI tumors, particularly pancreatic and liver tumors, is evolving, and Dr. Chang’s research focuses on ways to improve outcomes, reduce toxicity, and find novel combination therapy.  He has published multiple studies on SBRT for pancreatic and liver tumors, and is currently the principal investigator on a randomized SBRT trial for pancreatic cancer.

Dr. Chang has active collaborations with other members of the PCRG, including Drs. Shen, Fisher, Ford, Poultsides, Shen Kunz, and Visser.  Please edit

Selected relevant publications (Stanford PCRG members in bold):  Please edit as you see fit with a focus on pancreas cancer-related research

  1. Chang DT, Schellenberg DS, Shen J, Kim J, Goodman KA, Fisher GA, Ford JM, Desser T, Quon A, Koong AC Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas. Cancer 2009; 115(3): 665-72.
  2.  Schellenberg DS, Quon A, Minn AY, Graves EE, Kunz P, Ford JM, Fisher GA, Goodman KA, Norton JA, Koong AC, Chang DT 18Fluorodeoxyglucose-PET is prognostic of progression free and overall survival in locally advanced pancreas cancer treated with stereotactic radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Aug; 77(5); 1420-25.
  3. Murphy JD, Chang DT, Abelson J, Daly ME, Yeung HN, Nelson LM, Koong AC Cost-effectiveness of modern radiotherapy techniques in locally advanced pancreas cancer. Cancer 118:1119-29, 2012.
  4. Dholakia AS, Chaudhry M, Leal JP, Chang DT, Raman SP, Hacker-Prietz A, Su Z, Pai J, Oteiza KE, Griffith ME, Wahl RL, Tryggestad E, Pawlik T, Laheru DA, Wolfgang CL, Koong AC, Herman JM Baseline Metabolic Tumor Volume and Total Lesion Glycolysis is Associated With Improved Survival Outcomes in Patients with Locally Advanced Pancreatic Cancer Receiving Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):539-46.
  5. Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, Dinniwell R, Brierley J, Kavanagh BD, Dawson LA, Schefter TA Stereotactic Body Radiotherapy for Colorectal Liver Metastases: A Pooled Analysis. Cancer. 2011 Sep 1;117(17):4060-9.
  6. Pollom E, Alagappan M, von Eyben R, Kunz PL, Fisher GA, Ford JM, Poultsides GA, Visser BC, Norton JA, Kamaya A, Cox VL, Columbo LA, Koong AC, Chang DT Stereotactic body radiotherapy for pancreatic adenocarcinoma: single versus multi-fraction. Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):911-917.
  7. Herman JM, Chang DT, Goodman KA, Dholakia AS, RamanSP, Hacker-Prietz A, Iacobuzio-Donahue CA, Griffith MB, Pawlik TM, Pai J, O’Reilly E, Fisher G, Wild A, Rosati L, Zheng L, Wolfgang C, Laheru DA, Columbo LA, Sugar EA, Koong AC Phase II multi-institutional trial evaluating gemcitabine and stereotactic body radiation therapy for locally advanced unresectable pancreatic adenocarcinoma. Cancer. 2015 Apr 1;121(7):1128-37.
  8. Rao AD, Sugar EA, Chang DT, Goodman KA, Hacker-Prietz A, Rosati LM, Columbo L, O'Reilly E, Fisher GA, Zheng L, Pai JS, Griffith ME, Laheru DA, Iacobuzio-Donahue CA, Wolfgang CL, Koong AC, Herman JM Patient-Reported Outcomes of a Multi-Center Phase II Study Investigating Gemcitabine and Stereotactic Body Radiotherapy in Locally Advanced Pancreatic Cancer. Pract Radiat Oncol. 2016 Nov - Dec;6(6):417-424.
  9. Cui Y, Song J, Pollom E, Alagappan M, Shirato H, Chang DT, Koong AC, Li R Quantitative analysis of FDG-PET identifies novel prognostic imaging biomarkers in locally advanced pancreatic cancer patients treated with SBRT. Int J Radiat Oncol Biol Phys. 96(1):102-9, 2016.
  10. Toesca DAS, Pollom EL, Poullos PD, Flynt L, Cui Y, Quon A, von Eyben R, Koong AC, Chang DT Assessing Local Progression After Stereotactic Body Radiation Therapy For Unresectable Pancreatic Adenocarcinoma: CT versus PET. Pract Radiat Oncol. 7(2):120-125, 2017.
  11. Koong AJ, Toesca DA, von Eyben R, Pollom EL, Chang DT Reirradiation with Stereotactic Body Radiation Therapy After Prior Conventional Fractionation Radiation for Locally Recurrent Pancreatic Adenocarcinoma. Advances Radiat Oncol. 2017 Jan 18;2(1):27-36.
  12. Toesca DAS, Koong AJ, Poultsides GA, Visser BC, Haraldsdottir S, Koong AC, Chang DT Management of Borderline Resectable Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2017. (In press).