Garry Nolan, Rachford And Carlota Harris Professor in Microbiology and Immunology

Dr. Nolan’s areas of research include hematopoiesis, cancer and leukemia, autoimmunity and inflammation, and computational approaches for network and systems immunology. An innovative imaging platform invented by Dr. Nolan, termed CODEX, allows for nearly any inverted scope to be enabled to be a 50-parameter imager using DNA tagged antibodies. His prior contribution was co-development of CyTOF (a mass spectrometry-flow cytometry hybrid device) for single cell analysis that led to a significant increase in the number of assayable proteins per cell. Another focus of his lab is the development and utilization of machine learning algorithms to interpret the large high-dimensional datasets being produced by CyTOF, MIBI, and CODEX. All of these efforts enable a deeper understanding not only of normal immune function, but also inflammatory events and detailed substructures of and cancers.

Selected relevant publications (Stanford PCRG members in bold):

  1. Alcántara-Hernández M, Leylek R, Wagar LE, Engleman EG, Keler T, Marinkovich MP, Davis MM, Nolan GP, Idoyaga J. High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization. Immunity, 2017. PMID: 29221729

  2. Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG. Systemic Immunity is required for effective cancer immunotherapy. Cell, 2017. PMID: 28111070

  3. Curran MA, Ochoa MS, Molano RD, Pileggi A, Inverardi L, Kenyon NS, Nolan GP, Ricordi C, Fenjves ES. Efficient transduction of pancreatic islets by feline immunodeficiency virus vectors. Transplantation, 2002. PMID: 12177606

  4. Scappaticci FA, Contreras A, Smith R, Bonhourne L, Lum B, Cao Y, Engleman EG, Nolan GP.  Statin-AE: a novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity. Angiogenesis, 2001. PMID: 12197471

  5. Scappaticci FA, Smith R, Pathak A, Schloss D, Lum B, Cao Y, Johnson F, Engleman EG, Nolan GP. Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice. Mol Ther, 2001. PMID: 11237675