Hanlee P. Ji, M.D., Associate Professor of Medicine (Oncology Division)

Dr. Ji’s research interest is cancer genetics with an emphasis on clinically relevant questions that will improve our understanding of the cancer genetics of clinical phenotype and simultaneously improve patient care in oncology. He has performed and directed extensive bench research experience in the fields of genome sequencing technology development, human genetic analysis through human genome sequencing and molecular assay development. His research benefits from the various innovations in genomic and genetic technologies that his group has developed. One of the major topics of his research program involves elucidating the genetic mechanisms and biology underlying the metastatic spread of cancers with a specific focus on gastrointestinal malignancies. His group has also developed multiple bioinformatic methods and resources for application in cancer genome and genetic analysis. These tools and databases have served as the basis for several discoveries by his group and others.

Selected relevant publications (Stanford PCRG members in bold):

  1. Zheng GX, Lau BT, Schnall–Levin M, Jarosz M, Bell JM, Hindson CM, …, Ness KD, Hindson BJ and Ji HP. Megabase–scale haplotypes of germline and cancer genomes using linked–read sequencing. Nature Biotechnology, 2016. PMCID: PMC4786454

  2. Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MC, Rack PG, Neal JT, Chan CW, Yeung T, Xue G, Yuan J, Wilhelmy J, Robine S, Attardi AD, Plevritis SK, Hung KE, Chen CZ, Ji HP and Kuo CJ. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nature Medicine, 2014; 20(7): 769–77.

  3. Nadauld LD, Garcia S, Natsoulis G, Bell JM, Miotke L, Hopmans ES, Xu H, Pai RK, Palm C, JF Regan, Chen H, Flaherty P, Ootani A, Zhang NR, Ford JM, Kuo C and Ji HP. Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Genome Biology, 2014; 15(8): 428.

  4. Chang ST, Zahn JM, Horecka J, Kunz PL, Ford JM, Fisher GA, Le QT, Chang DT, Ji H and Koong AC. Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis. Journal of Translational Medicine, 2009; 105(7): 105.